Wixson began her modeling career in 2009 when she signed with Vision Models in Los Angeles. She was then rejected by IMG Models before signing with Marilyn in New York, Her runway debut was at the Spring 2010 New York Fashion Week in the Cynthia Steffe show.
Wixson then went on to Milan where she opened the Spring 2010 Prada show as an exclusive, thus making her one of the most successful newcomers that season. She has since walked in shows for many notable designers in the Milan, Paris, London, and New York fashion weeks including Miu Miu, Missoni, and Sophia Kokosalaki.
Wixson has been photographed in editorials for fashion magazines such as Love Magazine, Teen Vogue, i-D, Pop magazine, and Interview magazine.
In 2010 Wixson was the face of Miu Miu in the Spring/Summer campaign and she currently appears in the Miu Miu Fall/Winter 2010 campaign alongside Siri Tollerød, Ginta Lapina, and Daphne Groeneveld.
Wixson is ranked 19th on the Top 50 Models Women List by models.com. She is known for her unique looks and her lips, pout, and teeth.
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